Translational Development Scientist
Edison-New Brunswick Metro Area, NJ
The candidate will work with our translational development team and independently contribute to the development and execution of laboratory experiments to understand the activity of compounds and drug combinations.
A Bachelor s degree in the Life Sciences with 6+ years of hands-on research experience or Master s degree with 3+ years experience in a research environment
Experience with multi-parameter flow cytometry, tissue culture and working with PBMCs a must.
Proficient with general skills of molecular cell biology, such as RNA isolation, RT-PCR, Western Blotting, ELISA/Luminex, and basic cellular assays (e.g. proliferation/apoptosis).
Expierence in isolating T-cells and NK cells from PBMCs a plus.
Experience with PowerPoint, FlowJo and GraphPad Prism software
Solid understanding of scientific mechanisms and experimental techniques, with knowledge of signal transduction, immunology, cancer cell biology, drug discovery and translational medicine a plus.
The candidate will provide laboratory support by means of data generation and analysis for clinical trial biomarker strategies, publications and internal study reports. Responsibilities will include:
Performing in vitro and ex vivo testing of compounds and monoclonal antibodies on immune cells and tumor cells to evaluate mechanisms of drug response and resistance, to identify pharmacodynamic markers and to develop rational drug combination strategies
Performing in vitro co-culture assays with immune cells and tumor cells to assess drug effects
Performing molecular and cell biological techniques including, flow cytometry analysis, RNA preparation qRT-PCR analysis, western blot, proliferation and apoptosis assays
Participating in translational team meetings by presenting data and providing interpretation of experimental results
Working with multiple myeloma cell lines and immune cells derived from healthy donors and multiple myeloma patients. The candidate should have enthusiasm for helping support clinical programs, have knowledge of immuno-oncology and signal transduction pathways and technical expertise in flow cytometry and molecular based assays documented by relevant publications and work experience.