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SRA / Scientist - Cancer Cell Biology

San Francisco Metro Area, CA

Posted: 10/09/2018 Job Type: Scientific Job Number: JN -102018-22779
SENIOR OR PRINCIPAL RESEARCH ASSOCIATE/ SCIENTIST CANCER CELL BIOLOGY
The qualified candidate will join a team focused on small molecule oncology drug discovery, developing biochemical and cell-based assays and deciphering mechanism of action of lead molecules.
In this position you will support drug discovery efforts by providing cell biology expertise.

RESPONSIBILITIES:
  • Design and execute in vitro cell biology experiments
  • Culture a variety of cancer cell lines and primary cells
  • Develop and execute quantitative cell-based assays in 96-well or 384-well format
  • Analyze molecules mechanism of action utilizing flow cytometry, immunofluorescence, western, qPCR, apoptosis or other assays
  • Perform data analysis, reporting and integration with GraphPad Prism, Microsoft Office and other software packages
  • Contribute to lab management activities
  • Productively collaborate with Biology team members and across scientific disciplines
QUALIFICATIONS / EXPERIENCE:
  • BS or MS in related scientific discipline with more than 4 years of industry experience in cell biology and compound profiling for Senior or Principal Research Associate position
  • PhD/postdoc with cancer biology experience required for Scientist position
  • Ability to design, execute experiments and think independently
  • Extensive experience in cell culture, compound handling are must have
  • Proficiency in quantitative cell-based assays
  • Familiarity with liquid handlers/automation would be a plus
  • Experience with protein analysis by ELISA, MSD ELISA, western, flow cytometry, immunofluorescence
  • Experience with DNA and RNA isolation, qPCR and other RNA analysis techniques
  • Experience with retroviral/lentiviral vectors for generation of stable cell lines and gene knockdown/knockout using shRNA/CRISPR technologies
  • Excellent computer skills combined with data analysis
  • Must be detail oriented, well organized, and have strong communication skills
  • Capable of fully understanding scope of projects
  • Able to independently troubleshoot and identify solutions to arising issues
  • Excellent teamwork skills and the ability to work under the supervision of a senior member of the biology group, in a fast-paced, multi-disciplinary environment
  • Excellent work ethic, self-motivated, driven, dependable, hardworking
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