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Sr. Research Associate, Cell Biology

San Francisco Metro Area, CA

Posted: 10/09/2018 Job Type: Scientific Job Number: JN -102018-22779
The qualified candidate will join a team focused on developing and executing biochemical and cell-based assays for small molecule lead identification/optimization and deciphering their mechanism of action. In this position you will support drug discovery efforts by providing cell biology expertise and services.

  • Develop and execute biological assays (biochemical and cell-based) in 96-well or 384-well format
    • Compound Profiling / Screening Assays
  • Analyze molecules mechanism of action utilizing flow cytometry, immunofluorescence, western, qPCR, apoptosis assays
  • Culture a variety of cancer cell lines and primary cells
  • Prepare assay reagents, compound serial dilutions
  • Perform data analysis, reporting and integration with GraphPad Prism, Microsoft Office and other software packages
  • Contribute to or lead lab management activities
  • BS or MS in related scientific discipline
  • 3-6 years of industry experience in cell biology and compound profiling
  • Extensive experience in cell culture, compound handling are must have
  • Proficiency in biochemical and quantitative cell-based assays
  • Familiarity with plate readers and liquid handling platforms
  • Experience with protein analysis:
    • MSD
    • AlphaLISA/AlphaScreen
    • Western Blot
    • Flow Cytometry
    • Immunofluorescence
    • ELISA
  • Experience with DNA and RNA isolation, qPCR and other RNA analysis techniques
  • Experience with generation of stable cell lines, conditional gene knockdown/expression
  • Excellent computer skills combined with data analysis
  • Must be detail oriented, well organized, and have strong communication skills
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