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Snr Research Associate/Scientist

San Diego Metro Area, CA

Posted: 07/23/2019 Job Type: Scientific Job Number: JN -072019-25257
The position requires a bachelor s degree in a scientific discipline and 8+ years of laboratory experience, a Master degree with at least 4 years of experience or a PhD degree.

Structural and Chemical Biology

A highly talented and motivated structural biologist /protein chemist / biochemist is sought to assist the structural biology team with sample preparation for crystallography/cryo EM, assay development, biophysical and biochemical assays. The successful candidate will work within various discovery project teams and will have the opportunity to work on a state-of-the-art drug discovery environment, where discoveries can be immediately translated to treatments for serious diseases.

Responsibilities will include, but are not limited to, the following:
1. Independently design expression constructs and purify protein samples for structural studies and assays
2. Design and develop biochemical and biophysical assays to characterize protein samples and complexes
3. Analyze, document and present data in an organized and timely manner
4. Work with other members of the structural biology team to obtain diffracting crystals for multiple projects to support SAR studies
5. Ability to work in a fast-paced dynamic team environment; flexibility to adapt to changes with a positive attitude

Skills/Knowledge Required:

1. Excellent protein purification skills and knowledge of all techniques required to deliver high quality protein samples suitable for structural studies
2. Excellent protein purification troubleshooting skills to purify challenging/novel targets
3. Characterization of protein samples in complex with small molecules and other protein partners
4. Knowledge or experience with biochemical assays (cell based assay experience is advantageous)
5. Experience with macromolecular crystallization and X-ray crystallography is advantageous
6. Knowledge or experience with X-ray crystallography data collection and analysis is desirable but not required
7. Experience with membrane protein purification and LCP crystallization is desirable but not required
8. Cryo EM experience is highly desirable but not required
9. Excellent communication, presentation, collaboration and organizational skills are required
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