Senior Research Associate
San Diego Metro Area, CA
The Protein Homeostasis TCoE is built on our legacy IMiD compounds. This class of drugs promotes the destruction of transcription factors Ikaros and Aiolos via the cereblon E3 ligase complex, thereby achieving therapeutic efficacy in a range of human diseases. The molecular mechanism group in the Protein Homeostasis TCoE is seeking a wet-lab scientist to assist the development of novel cereblon modulating agents that target cancer-specific prosurvival programs to treat various cancer types, as well to define the underlying mechanism of response and resistance. Better understanding of the MOA of these agents will help us pinpoint the right disease indications, select sensitive patient population and devise rational combination therapies to combat resistance. The successful candidate will have the opportunity to work closely with discovery project teams and scientists across the PH TCoE functional areas and to present his or her work at project team meetings and to the senior research leadership.
Extensive experience working with RNA and generating next generation sequencing libraries
Extensive wet-lab experience with molecular and cell biology including molecular cloning, western blot, immunoprecipitation, flow cytometry, realtime-qPCR, ELISA, lentivirus preparation and infection, etc.
Extensive experience with Cas9-CRISPR mediated gene editing and RNAi
Highly motivated and strong team player with a high degree of independence
Innovative and critical thinking
Excellent time management and organizational skills
Strong communication skills, both written and oral
Bachelor s degree in a scientific discipline with at least 3 years work experience or Master s degree with at least 2 years work experience