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Senior Research Associate

San Diego Metro Area, CA

Posted: 08/07/2019 Job Type: Scientific Job Number: JN -082019-25382

Summary/Scope:

The Protein Homeostasis TCoE is built on our legacy IMiD compounds. This class of drugs promotes the destruction of transcription factors Ikaros and Aiolos via the cereblon E3 ligase complex, thereby achieving therapeutic efficacy in a range of human diseases. The molecular mechanism group in the Protein Homeostasis TCoE is seeking a wet-lab scientist to assist the development of novel cereblon modulating agents that target cancer-specific prosurvival programs to treat various cancer types, as well to define the underlying mechanism of response and resistance. Better understanding of the MOA of these agents will help us pinpoint the right disease indications, select sensitive patient population and devise rational combination therapies to combat resistance. The successful candidate will have the opportunity to work closely with discovery project teams and scientists across the PH TCoE functional areas and to present his or her work at project team meetings and to the senior research leadership.

Skills/Knowledge Required:

Extensive experience working with RNA and generating next generation sequencing libraries

Extensive wet-lab experience with molecular and cell biology including molecular cloning, western blot, immunoprecipitation, flow cytometry, realtime-qPCR, ELISA, lentivirus preparation and infection, etc.

Extensive experience with Cas9-CRISPR mediated gene editing and RNAi

Highly motivated and strong team player with a high degree of independence

Innovative and critical thinking

Excellent time management and organizational skills

Strong communication skills, both written and oral

Prerequisite:

Bachelor s degree in a scientific discipline with at least 3 years work experience or Master s degree with at least 2 years work experience

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