Senior Research Associate
San Diego Metro Area, CA
Bachelor s degree in a scientific discipline with at least 4 years work experience or Master s degree with at least 2 years work experience
The Protein Homeostasis TCoE is built on our legacy IMiD compounds. This class of drugs promotes the destruction of transcription factors Ikaros and Aiolos via the cereblon E3 ligase complex, thereby achieving therapeutic efficacy in a range of human diseases. The molecular mechanism group in the Protein Homeostasis TCoE is seeking a wet-lab scientist to assist the development of novel cereblon modulating agents that target cancer-specific prosurvival programs to treat various cancer types, as well to define the underlying mechanism of response and resistance. Better understanding of the MOA of these agents will help us pinpoint the right disease indications, select sensitive patient population and devise rational combination therapies to combat resistance. The successful candidate will have the opportunity to work closely with discovery project teams and scientists across the PH TCoE functional areas and to present his or her work at project team meetings and to the senior research leadership.
Responsibilities will include, but are not limited to, the following:
Utilize RNAi and CRISPR to determine the disease relevance of novel therapeutic targets
Explore the structural and activity relationship (SAR) of small drug inhibitors using various cell based assays including western, RT-PCR, immunofluorescent staining, and flow cytometry.
Define the MOA of candidate agents using hypothesis-driven approach as well as unbiased genome-wide CRISPR screen
Design and develop novel assays
Document, interpret and troubleshoot results
Convey data analysis and interpretation to supervisor and colleagues
Communicate with peers and supervisors and foster teamwork
Contribute to collaborative efforts
Strong commitment to quality and reproducibility
Supervise or guide research staff