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Senior Research Associate

San Diego Metro Area, CA

Posted: 08/05/2019 Job Type: Scientific Job Number: JN -082019-25367

PREREQUISITES:

Bachelor s degree in a scientific discipline with at least 4 years work experience or Master s degree with at least 2 years work experience

DESCRIPTION:

SUMMARY/SCOPE

The Protein Homeostasis TCoE is built on our legacy IMiD compounds. This class of drugs promotes the destruction of transcription factors Ikaros and Aiolos via the cereblon E3 ligase complex, thereby achieving therapeutic efficacy in a range of human diseases. The molecular mechanism group in the Protein Homeostasis TCoE is seeking a wet-lab scientist to assist the development of novel cereblon modulating agents that target cancer-specific prosurvival programs to treat various cancer types, as well to define the underlying mechanism of response and resistance. Better understanding of the MOA of these agents will help us pinpoint the right disease indications, select sensitive patient population and devise rational combination therapies to combat resistance. The successful candidate will have the opportunity to work closely with discovery project teams and scientists across the PH TCoE functional areas and to present his or her work at project team meetings and to the senior research leadership.

Responsibilities will include, but are not limited to, the following:

Utilize RNAi and CRISPR to determine the disease relevance of novel therapeutic targets

Explore the structural and activity relationship (SAR) of small drug inhibitors using various cell based assays including western, RT-PCR, immunofluorescent staining, and flow cytometry.

Define the MOA of candidate agents using hypothesis-driven approach as well as unbiased genome-wide CRISPR screen

Design and develop novel assays

Document, interpret and troubleshoot results

Convey data analysis and interpretation to supervisor and colleagues

Communicate with peers and supervisors and foster teamwork

Contribute to collaborative efforts

Strong commitment to quality and reproducibility

Demonstrate adaptability

Supervise or guide research staff

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