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Senior Research Associate

San Diego Metro Area, CA

Posted: 08/28/2018 Job Type: Scientific Job Number: JN -082018-22423
The molecular mechanism group in the Protein Homeostasis TCoE is seeking a Senior Research Associate (one-year contractor) to assist the development of novel drugs that target cancer-specific prosurvival programs to treat various cancer types, as well to define the underlying mechanism of response and resistance. Better understanding of the MOA of these drugs will help us pinpoint the right disease indications, select sensitive patient population and devise rational combination therapies to combat resistance. The successful candidate will have the opportunity to work closely with discovery project teams and scientists across the PH TCoE functional areas and to present his or her work at project team meetings and to the senior research leadership.

Responsibilities will include, but are not limited to, the following:

Identify and validate novel drug targets using cell-based assays
Utilize RNAi and CRISPR to determine the disease relevance of novel drug targets
Perform cellular experiments to help define the SAR of drugs
Utilize genetic and pharmacological approaches to define the MOA of candidate drugs
Design and develop novel assays
Document, interpret and troubleshoot results
Convey data analysis and interpretation to supervisor and colleagues
Communicate with peers and supervisors and foster teamwork
Contribute to collaborative efforts
Strong commitment to quality and reproducibility
Demonstrate adaptability

Extensive wet-lab experience with routine molecular, cellular and genetic biology tools
Extensive experience with Cas9-CRISPR mediated gene editing and RNAi
Highly motivated and strong team player with a high degree of independence
Innovative and critical thinking
Excellent time management and organizational skills
Strong communication skills, both written and oral
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