Senior Associate Scientist
San Diego Metro Area, CA
Responsibilities will include:
We are seeking a highly motivated Senior Associate Scientist with experience in hematology and immuno-oncology-based assays to participate in drug discovery research. Emphasis will be in primary tumor cell biology assay development. The successful candidate will work collaboratively in a multi-disciplinary environment to discover novel drugs and to understand their molecular mechanism of action. Responsibilities will include development of primary tumor cell and cell-line based co-culture assays to support compound development, inform clinical combination strategies, understand mechanism of action, and help biomarker selection. Experience with developing high-throughput screening assays is required. The successful candidate will work closely with discovery and development project teams and scientists across the PH TCoE functional areas.
Bachelor s degree in molecular biology, cell biology, or related scientific discipline with at least 8 years laboratory experience or master s degree with at least 5 years industry experience.
Hands-on experience in mammalian cell culture using single cells and co-culture cell models. Experience using single compound treatment and combination treatment studies is essential.
Extensive experience designing, implementing and analyzing compound effect using multiple platforms (flow cytometry, Incucyte, Cellomics, Western blot, ELISA, immunoprecipitation, immunofluorescence and functional assays such as cell cycle and apoptosis).
Experience with the use automation instruments is required.
Excellent communication, presentation and organizational skills are required as well as the ability to independently design, execute, and troubleshoot experiments through completion.
Data analysis skills and experience with a variety of scientific software applications are required
Ability to work in a fast-paced dynamic team environment; flexibility to adapt to changes with a positive attitude.