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Scientist

Cambridge Metro Area, MA

Posted: 06/29/2018 Job Type: Scientific Job Number: JN -062018-21960
Description:
We are seeking a highly motivated and skilled contractor to join our Biochemistry & Biophysics team within Translational Sciences Platform. A successful candidate will be responsible for developing larger scale quantitative proteomic approaches to identify and verify the differential expression of surface membrane proteins across the tumor tissues and understand their respective co-localized partners. In addition, he or she will perform affinity enrichment associated with proteomic approach to characterize and identify the interacting proteins, and elucidate mechanism of action for antibodies or small molecules which modulate drug targets.

Skills:
  • 3 years of experience in the area of biochemistry or bioanalytics
  • Candidate should have in-depth knowledge of and hands-on experience with LC-MS/MS of proteins and peptides.
  • Candidate should have ability to operate and maintain multiple mass spectrometry platforms (e.g. Orbitrap, Q-Exactive, Q-Trap mass spectrometers etc).
Candidate should have strong experience in proteomics sample preparation for mass spectrometry, such as cells and tissue membrane extraction, immunoprecipitation, protein digestion and so on, and familiar with softwares for protein identification and validation.
BS or MS degree in biological science or bioanalytical chemistry
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