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Boston Metro Area, MA

Posted: 06/22/2018 Job Type: Scientific Job Number: JN -062018-21903
Responsibilities will include, but are not limit to, the following:
  • Provides direct on-site early formulation development support to enable efficacy, PK, and toxicology studies for small molecule Drug Discovery efforts.
  • Provides drug substance characterization including crystallinity assessment, solubility determination, and physicochemical stability evaluation.
  • Offers solubility enhancement of poor water soluble compounds by applying various solubilization techniques.
  • Develops understanding of the impact of physiochemical and solid state properties on drug candidate performance.
  • Perform in-silico biopharmaceutical evaluation to support drugability assessment.
  • Inform and influence drug discovery team finding new chemical entities with desirable physicochemical and biopharmaceutical properties.
  • Recommends potential clinical formulation to the project team based on physicochemical and biopharmaceutical properties of the drug candidate.
  • Demonstrated experience in discovery and preclinical support, preformulation screening, solid state characterization and aiding formulation design.
  • Sound knowledge of pharmaceutical research and development process.
  • Good written and verbal communication skills.
  • M.S./Ph.D.(preferred) in pharmaceutics, pharmaceutical science, pharmaceutical chemistry or related scientific discipline required.
  • Minimum of 1 to 2 years experiences in pharmaceutical industry in drug discovery and development.
  • 1 to 2 years of relevant experience in discovery and preclinical support, preformulation screening, early formulation development, solid state characterization, and development in the pharmaceutical industry.
  • Excellent communication, interpersonal skill to collaborate with others on projects.
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