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Scientist - Cellular / Molecular

Newark Metro Area, NJ

Posted: 06/12/2018 Job Type: Scientific Job Number: JN -062018-21819
Description:
A BS/MS degree in the Life Sciences with at least 3+ years of research experience a
Experience with tissue culture, primary cell culture, co-cultures and working with PBMCs.
Flow cytometry experience.
Proficient with general skills of molecular cell biology, such as RNA isolation, RT-PCR, Western Blotting, Luminex, and basic cellular assays (e.g. proliferation/apoptosis).
Experience with PowerPoint, FlowJo and GraphPad Prism software
  • Solid understanding of scientific mechanisms and experimental techniques, with knowledge of signal transduction, immunology, cancer cell biology, drug discovery and translational medicine a plus.

  • Performing in vitro and ex vivo testing of compounds on immune cells and tumor cells to evaluate mechanisms of drug response and resistance, to identify pharmacodynamic markers and to develop rational drug combination strategies
Performing in vitro co-culture assays with immune cells and tumor cells to assess drug effects by flow cytometry
Performing molecular and cell biological techniques including, flow cytometry analysis, RNA preparation qRT-PCR analysis, western blot, and proliferation assays
Participating in translational team meetings by presenting data and providing interpretation of experimental results

Working with multiple myeloma cell lines and immune cells derived from healthy donors and multiple myeloma patients. The candidate should have enthusiasm for helping support clinical programs, have knowledge of immuno-oncology and signal transduction pathways and technical expertise in flow cytometry and molecular based assays documented by relevant publications and work experience.

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