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Scientist, Translational Development

San Francisco Metro Area, CA

Posted: 03/07/2019 Job Type: Scientific Job Number: JN -032019-23868
Translational Development is a department within the Research and Development organization that facilitates the transition of drug candidates from drug discovery through early- and late-stage clinical development. Early-stage translational development activities enable rational determination of dose-schedule and responsive patient populations, based on deep understanding of drug mechanism of action. Late-stage translational development activities build upon the early work, additionally exploring mechanisms of resistance, rational drug combinations and product differentiation. The late-stage translational development function is responsible for the development of translational strategies to support the development, and maximize the potential, of therapies post-clinical proof-of-concept, including registrations and life-cycle management.

Summary and Scope:

We are seeking a talented and highly motivated Scientist (B.S., M.S. or a Ph.D. level candidate) for a full-time contract position in the Translational Development & Diagnostics group. to conduct translational research in myeloid malignancies (i.e., acute myelogenous leukemia). This role presents an opportunity to interface with a group of scientists and clinicians.

The incumbent will work with cell-based assays and primary cell models to evaluate drug mechanisms of action and credential novel biomarkers, utilizing multiple assay formats (for example, flow cytometry, DNA/RNA sequencing methods), for implementation into clinical trials.

Responsibilities will include, but are not limited to, the following:

1. Independently design, plan and conduct lab-based experiments based on testable hypotheses
2. Drive and manage the development of biomarker assays internally and validation at contract research organizations.
3. Interface with cross functional areas, such as discovery research, biospecimen operations, and computational biology, to advance scientific objectives.

Skills/Knowledge Required:

1. B.S. with 8+ years, M.S. with 5+ years, or Ph.D. with 0+ years post-degree cell and molecular biology, immunology, or a related discipline. Hematology/Oncology and/or epigenetics experience is preferred (but not a requirement).
2. Strong interest in translational research (biomarker implementation) and highly motivated to scientifically contribute to development of therapeutics for unmet medical needs.
3. A track record of rigorous bench research and independent thinking
4. Hands-on experience with cell culture, bone marrow and primary cells (AML and/or HSCs)
5. Expertise in multi-parameter flow cytometry assay work-up and data analysis (FACSDiva, FlowJo) is required.
6. Basic molecular biology skills: i.e., Western blot, DNA and RNA isolation, qPCR and transcriptional profiling (single cell or bulk RNAseq etc)
7. Ability to tackle complex technical issues and propose solutions
8. Self-motivated, ability to prioritize and manage time efficiently.
9. Excellent interpersonal, verbal and written communication and organization skills, manage externalized research.
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