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Scientist, Protein Sciences

San Mateo Metro Area, CA

Posted: 08/06/2019 Job Type: Scientific Job Number: JN -082019-25374

JOB DESCRIPTION:

We are seeking for a talented, highly motivated Protein Scientist to join our collaborative efforts in the discovery and development of antibody therapeutics for novel immune-oncology targets. This position will report directly to the Group Leader of Protein Sciences in Antibody Development. The successful candidate will be offered a great career advancement potential with the main function of implementing new platforms in protein sciences and protein/antibody engineering. The job will require independently designing constructs, expressing and characterizing proteins / antibodies, as well as presenting data in project team meetings and managing CROs/vendors.

DUTIES / RESPONSIBILITIES

Design recombinant protein and antibody expression constructs for mammalian and insect cell expression systems

Understand the biology and rationale behind protein/antibody design/engineering

Develop and implement new protein/antibody expression and purification platforms

Present results and interpretations in research project team meetings

Proper documentation of reagent inventories, data and reports

Manage CROs for outsourcing non-core activities

Stay on top of the latest scientific developments in the fields of protein sciences and protein/antibody engineering

MUST HAVE

Demonstrated ability to design expression constructs for novel and challenging proteins

Proficient with molecular techniques such as site-directed mutagenesis, PCR, ligation independent cloning and experience with software such as VectorNTI or DNASTAR

Experience in cell culture techniques including aseptic maintenance of cell lines and transient/stable transfection

Expert in secreted protein purification using a variety of chromatography resins, methods and FPLC/HPLC systems

Skilled in the techniques of protein characterization including SDS-PAGE, Western Blot and analytical SEC/IEX

Strong understanding of protein chemistry, biophysics of protein-protein interactions and protein stability

Knowledge in protein structures and experience with modeling software such as PyMOL

GOOD-to-HAVE

Antibody engineering

Membrane protein expression and purification

Additional protein/antibody analytical methods including analytical HIC/RP-HPLC, SEC-MALS, DSF, DSC, analysis of binding affinity using Octet or Biacore

Cell-based activity assays

REQUIREMENTS

This is a Scientist level position for candidate with Ph.D. in Protein Biochemistry, Protein Engineering or related disciplines

Post-doctoral or biotechnology industry experience is valued but not necessary

Strong track record in biological research as indicated by publications in peer-reviewed journals

Values great team relationships and be honest and open in communication

Flexible and versatile with the ability to successfully manage multiple priorities

Capable of multitasking with great organizational skills

Thrives in a fast paced and dynamic team environment; fast learning and adaptable

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