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Research Associate

San Diego Metro Area, CA

Posted: 01/16/2019 Job Type: Scientific Job Number: JN -012019-23410
Description:
SUMMARY:

Seeks a highly motivated cell and molecular biology contractor to join our drug discovery research team. The successful candidate will be part of the company s protein homeostasis solid tumor drug discovery group. This group is composed of scientists focused on development, characterization and utilization of preclinical in vitro cancer models. The successful candidate will assist the platform team in growing and maintaining mammalian cell lines in 2D/3D culture systems, managing cryopreservation of tissue and cells, and performing high-throughput drug screens using our chemical library.

RESPONSIBILITIES:
Maintain and passage 2D/3D patient-derived tumor lines
Manage cryopreservation of tissues and cell lines
Perform dose-response curve experiments to assess drug efficacy
Optimize and perform high-throughput 2D/3D drug screens
Perform and report on qPCR based experiments
Utilize FACS and Western blots for cell analysis
Maintain an accurate and complete laboratory notebook and other records according to company rules
Write laboratory protocols and standard operating procedures
Perform a wide variety of basic molecular biology procedures
Assist platform team members with house-keeping tasks

REQUIRED SKILLS:
Solid hands-on experience with basic cell biology techniques such as:
o Mammalian cell culture (3D culture experience is a plus)
o Drug screening protocols, assessing cell viability
o Cryopreservation
Solid hands-on experience with basic molecular biology techniques such as:
o DNA and RNA extraction and quantification
o Western blotting
o PCR and qPCR
Preference will be given to candidates with hands-on experience with 3D culture techniques
Attention to detail and ability to perform delicate manual tasks in a laboratory
Interest and proven aptitude in learning and applying new laboratory techniques, skills and instrumentation
Ability to work both independently and as part of a team
Strong communication skills (able to clearly communicate problems, protocols, and results to colleagues, both in writing and verbally), and ability to keep complete and detailed records
Drive to seeing projects through to successful completion
Able to interact with colleagues of diverse backgrounds and contribute to team goals
Fluency in the use of Microsoft Word, Excel and PowerPoint

EDUCATION:
M.Sc. degree in the biological sciences with 0-2 years of hands-on cell and molecular biology experience
B.Sc. degree with 2+ years of hands-on cell and molecular biology experience
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