San Diego Metro Area, CA
The Structural and Chemical Biology department is looking for a self-motivated and experienced contract associate scientist or senior associate scientist to work on the development and execution of cell-based assays to profile small molecule compounds. The hands-on experience on small molecule drug discovery for oncology and/or immunology indications is a plus. The successful candidate should have a B.S. with at least 4 year experience (6 year for senior associate scientist) or M.S. degree with 2 year (4 years for senior associate scientist) working experience in cellular /molecular biology at academic institute or industrial company.
Responsibilities will include, but are not limited to, the following:
Independently execute cell based assays to profile small molecule compounds and provide SAR report to chemistry team
Develop and optimize cell based assays to characterize small molecular compounds with minimal supervision
Experience on cell culture to maintain cell lines or primary cells for cell-based assay development and compound profiling.
Independently document/record experimental protocols, conduct data analysis, upload assay results to database, and record results in electric notebook.
Analyze/interpret/present the experimental results to the group/project team meeting
Collaboratively work with group and project scientists in a matrix environment
Previous hands-on experience with cellular and molecular technologies: western blot, quantitative PCR, ELISA, CTG/MTS-based cell cytotoxic assay and flow cytometry.
Previous hands-on experience in cell culture to maintain cell lines or primary cells for cell-based assay development. Experience with primary immune cells such as T, or B cells is a plus.
Previous experience with CRISPR is a plus.
Be comfortable to work in a fast-changing working direction/assignment environment.