Cambridge Metro Area, MA
The successful candidate will join a dynamic, multi-disciplinary team of scientists in the Oncology Pharmacology group, playing a key role in the development of in vivo models of cancer and their use for evaluating new drug candidates.
In addition, applicants will exhibit strong communication and organizational skills, critical problem-solving abilities, and a commitment to excellence. Prior experience with oncology xenograft models for use in efficacy and PK/PD and studies is a plus. Prior experience standard in vitro assays is a plus but not necessary (rtPCR, qPCR, ELISA, Western blots)
Additional responsibilities include:
Develop, validate, and implement relevant in vivo oncology-related xenograft models including subcutaneous and orthotopic xenograft models, syngeneic tumor models and PBMC and/or T cell adoptive transfer models for profiling the pharmacological effects of drug candidates.
Responsible for data capture and reporting
Contribute to ex vivo pharmacodynamic studies tailored to the molecular target of interest, including cellular and molecular readouts..
Hands on in vivo skills necessary to execute rodent oncology models including i.v., i.p. and p.o. dosing, tumor implantation and tissue collection techniques.
BS or technical equivalent with expertise in pharmacology, in vivo physiology or related biological science. 1-2 plus years of industry experience with in vivo models