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Research Associate / Senior Research Associate

San Francisco Metro Area, CA

Posted: 08/20/2019 Job Type: Scientific Job Number: JN -082019-25466

Translational Development:


Our team is focusing on translational development to develop target validation approaches, define appropriate disease models, and catalyze early engagement between Discovery and Early Development teams to define biomarkers and patient selection strategies. We also work with Clinical Pharmacology to define starting doses and schedules for dose escalation in Phase 1 studies. Rational combinations of novel molecules is also a focus.


We are seeking a highly motivated and dynamic individual to join our translational development group. The successful candidate will have extensive experience performing laboratory work, including handling cell cultures and performing analysis of protein and DNA / RNA samples using a variety of methodologies. Experienced in the design and development of cell based assays using various technology platforms. The candidate will use current (or new) techniques to address questions of drug mechanism of action, drug differentiation and drug sensitivity / resistance. Experience in epigenetics is a plus.


KNOWLEDGE/SKILLS/ABILITIES (KSA s):


Requires a Master s degree in a scientific discipline with at least 4 years work experience, or Bachelor s degree with at least 6 years work experience in cancer research.


MOST IMPORTANT:

Strong hands-on experience in mammalian cell cultures and molecular techniques (DNA/RNA, PCR, western).

Prior RA experience either in academia or/and industry

Core cell biology skills including cell-based assays for growth / viability and signal transduction


A PLUS:

Cell-based high throughput assays, siRNA, shRNA, CRISPR etc.

Microscopy, immunoprecipitation, chromatin precipitation, ELISA etc.

Immunohistochemistry and immunofluorescence techniques

Knowledge of oncology and immunology is a plus


ALSO EXPECTED:

Able to multitask, highly motivated, innovative and a strong team player

Able to conduct experimental work independently, with accurate, detailed record-keeping

Excellent time management and organizational skills

Prepare and discuss scientific data in a clear, concise and accurate manner

Effective oral and written communication

Strong problem-solving skills

Flexibility in case of changing priorities

Set up and utilize a wide range of in vitro oncology models

Execute experiments to characterize small molecule inhibitors

Able to identify scientific and technical problems and potential solutions

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