Research Associate - Histology
San Mateo Metro Area, CA
- Execute on scientific and technical efforts related to histology and other tissue-based assays from study design (including appropriate tissue selection and techniques) to microscopic analysis, interpretation, and reporting.
- Design and optimize novel automated singleplex and multiplex IHC and ISH assays to characterize the binding properties of therapeutic antibodies, identify tissue-based markers of efficacy from animal studies, and assist with exploratory biomarker development in search of target engagement and drug response in clinical trial samples
- Manage automated whole slide image analysis algorithms to measure protein expression levels and interpret results from large histological studies
- Examine human disease, its pathology in relevant organs, and comparison of relevant transgenic animals that model the disease to support safety and toxicological characterization for drug development