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Research Associate, Cell & Molecular Biology

San Diego Metro Area, CA

Posted: 06/15/2018 Job Type: Scientific Job Number: JN -062018-21853
he Celgene Protein Homeostasis Thematic Center of Excellence (PH TCoE) is seeking an experienced scientist for a contract position within an exciting multi-disciplinary target discovery and mass spectrometry group. The successful candidate will have well-documented expertise in molecular cloning and cellular biology and biochemistry. The candidate will work collaboratively in dynamic laboratory that uses computation, cell-based models, protein biochemistry, and mass spectrometry to identify and characterize new targets for small molecule drug discovery. Our perfect candidate will exhibit excellent organization, creative scientific thinking, a great communicative attitude, and a love for the lab.

Responsibilities will include, but are not limited to, the following
Design and conduct in vitro cell biology experiments using mammalian cell lines.
Perform mechanism of action experiments with compounds and genetic manipulation.
Perform DNA/RNA/Protein analyses including qPCR, western blotting, immunoprecipitation, and mass spectrometry as necessary for each experiment.
Develop and optimize new assays for various projects.
Plasmid cloning: Gateway & Restriction cloning, Mutagenesis, PCR.
Help set up a proteomics sample preparation workflow and create new technologies.
Prompt notebook documentation. Present and publish findings.

*** MUST HAVE: Highly experienced in molecular biology and plasmid cloning.
*** MUST HAVE: Excellent mammalian cell culture technique.
*** MUST HAVE: Fluorescent microscopy, qPCR, Westerns, cell proliferation assays, shRNA, CRISPR.
Bachelor s degree in a scientific discipline with at least 4 years work experience or Master s degree with at least 2 years work experience. Manager not interested in PhD candidates.
Working knowledge of proteomic sample preparation & immunoprecipitation is desired.
Experience using cancer cell models is desired.
Data analysis and data handling skills: Must be fluent using Windows PC & Excel. Knowledge of Python, R, Knime, or Vortex is a plus.
Previous industrial or academic lab experience in gene function studies.
Excellent organization and communication.
Excitement for scientific discovery and a positive attitude.
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