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Research Associate, Cell & Molecular Biology

San Diego Metro Area, CA

Post Date: 06/15/2018 Job ID: JN -062018-21853 Job Type: Scientific
Description:
he Celgene Protein Homeostasis Thematic Center of Excellence (PH TCoE) is seeking an experienced scientist for a contract position within an exciting multi-disciplinary target discovery and mass spectrometry group. The successful candidate will have well-documented expertise in molecular cloning and cellular biology and biochemistry. The candidate will work collaboratively in dynamic laboratory that uses computation, cell-based models, protein biochemistry, and mass spectrometry to identify and characterize new targets for small molecule drug discovery. Our perfect candidate will exhibit excellent organization, creative scientific thinking, a great communicative attitude, and a love for the lab.

Responsibilities will include, but are not limited to, the following
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Design and conduct in vitro cell biology experiments using mammalian cell lines.
Perform mechanism of action experiments with compounds and genetic manipulation.
Perform DNA/RNA/Protein analyses including qPCR, western blotting, immunoprecipitation, and mass spectrometry as necessary for each experiment.
Develop and optimize new assays for various projects.
Plasmid cloning: Gateway & Restriction cloning, Mutagenesis, PCR.
Help set up a proteomics sample preparation workflow and create new technologies.
Prompt notebook documentation. Present and publish findings.


Skills:
*** MUST HAVE: Highly experienced in molecular biology and plasmid cloning.
*** MUST HAVE: Excellent mammalian cell culture technique.
*** MUST HAVE: Fluorescent microscopy, qPCR, Westerns, cell proliferation assays, shRNA, CRISPR.
Bachelor s degree in a scientific discipline with at least 4 years work experience or Master s degree with at least 2 years work experience. Manager not interested in PhD candidates.
Working knowledge of proteomic sample preparation & immunoprecipitation is desired.
Experience using cancer cell models is desired.
Data analysis and data handling skills: Must be fluent using Windows PC & Excel. Knowledge of Python, R, Knime, or Vortex is a plus.
Previous industrial or academic lab experience in gene function studies.
Excellent organization and communication.
Excitement for scientific discovery and a positive attitude.

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