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Lipid Nanoparticle Formulation Scientist

San Diego Metro Area, CA

Posted: 01/15/2019 Job Type: Scientific Job Number: JN -012019-23405
Education:
Ph.D. in Chemistry, Biochemistry, Pharmaceutical Sciences, Chemical Engineering, Biomedical Engineering or closely-related discipline with an emphasis in delivery of nucleic acids.
M.S. or B.S. in similar fields acceptable with a minimum of 6+ years of relevant industrial experience
Role:
The successful candidate will design and manufacture lipid nanoparticles for the delivery of nucleic acids to mammalian cells as well as other novel nanoparticle-based drug delivery formulations containing small molecules, RNA, DNA and proteins.
The work is multi-functional and includes formulation design, analytical methods development, physical characterization, experimental design, sample analysis and interpretation of results.
The candidate with be expected to oversee the synthesis of novel excipients and interact closely with other researchers in the design of lipid nanoparticle delivery formulations.
This is a hands-on, laboratory-based role in a highly collaborative early development environment.


1. Must have experience with lipid nanoparticle delivery of RNA or DNA for transfection to mammalian cells.
2. Must have experience in nanoparticle formulation and nanoparticle drug delivery.
3. Must have knowledge of the design, synthesis, characterization and structure-property relationships of lipids and other lipid-like molecules used as transfection agents.
4. Background in the biology of plasmid transfection and expression is a plus.
5. Experience and technical proficiency with HPLC, gel-based and other methods for analysis and quantification of small molecules, DNA and proteins is preferred.
6. Previous experience and technical proficiency in the physical characterization of nanoparticles, including particle sizing is a plus.
7. Familiarity with lab-scale nanoparticle preparation techniques, including microfluidics technology, is preferred.
8. Experience with alternate pharmaceutical manufacturing technologies homogenization, lyophilization, micronization, etc. is a plus.
9. Strong interpersonal, communication, collaboration and problem solving skills.
10. Ability to document work and proven record of scientific technical writing.

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