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Group Leader, Protein Sciences

San Mateo Metro Area, CA

Posted: 11/15/2018 Job Type: Scientific Job Number: JN -112018-23066

Senior / Principal Scientist - Protein Sciences

RESPONSIBILITIES:

  • Lead the Protein Sciences Group
  • Design recombinant protein and antibody expression constructs for mammalian expression systems
  • Support adherent and suspension mammalian cell lines (CHO, HEK293)
  • Seed and transfect cells in variety of cell culture flasks
  • Employ a variety of protein purification methods to isolate recombinant proteins
  • Manage proper reagent inventories, data and reports
  • Organize protein production activities to meet research program goals
  • Present results and interpretations research project team meetings

TECHNICAL SKILLS:

  • Enable and design expression constructs for novel proteins
  • Molecular techniques such as site-directed mutagenesis, PCR, TA cloning, and LIC method (In-Fusion cloning), restriction digests, and electrophoresis
  • Mammalian cellular techniques including aseptic maintenance of cell lines and transient transfection
  • Protein purification including novel proteins using a variety of chromatography resins and methods
  • Protein characterization including SDS-PAGE, Western Blot and analytical SEC
  • Ability to troubleshoot using innovative strategies in solving problems
  • Track record of being flexible with multiple priorities and capable of multitasking.
  • Desirable: Experience with scientific software, such as VectorNTI, Sequencher, DNAStar, etc.

QUALIFICATIONS:

  • Ph.D. in Biochemistry or other related fields and a Postdoc
  • 2-5 years biotechnology industry experience with 2+ years of practical hands-on experience in molecular techniques, cell culture, transient transfection of mammalian cells protein characterization and protein purification
  • People leadership & management experience
  • Thrive working in a fast paced and dynamic team environment
  • Value great team relationships and are honest and open in your communication
  • Pursue excellence especially in the antibody-based drug discovery space
  • Inspired by curiosity and responsible risk-taking
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