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Formulation Scientist

San Diego Metro Area, CA

Posted: 03/21/2018 Job Type: Scientific Job Number: JN -032018-21176
This scientist will conduct hands-on laboratory work such as solubility, stability, formulation development for prelinical animal species, solid state characterization, and preliminary salt/polymorph screening to inform the risk in pharmaceutical development. Formulation development can include vehicle screening, small scale screening for amorphous solid dispersion or nanosuspensions. Characterization work can include HPLC, XRD, TGA, DSC, and DLS. The associate scientist will collaborate with Discovery team in San Diego. The associate scientist will participate in the departmental meeting and present on their work on a regular basis.

Responsibilities include, but are not limited to, the following:
1. Provides direct on-site preformulation support to enable efficacy, PK, and toxicology studies for San Diego based discovery groups
2. Conducts drug substance physicochemical characterization to evaluate the risk in development
3. Conducts solubilization enhancement studies, and supports enabled formulation development (amorphous solid dispersion, nano formulation, lipid based formulation) to improve exposure in the preclinical species
4. Conduct solid state characterization and preliminary salt and polymorph screening
5. Instrument maintenance

M.S. or PhD in Chemistry, Pharmaceutical Sciences, or related scientific discipline. Experience in the pharmaceutical industry in discovery support, or formulation development group. Preference for 2-4+ years experience but entry level PhD candidates will be considered.
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