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Associate Scientist

San Diego Metro Area, CA

Post Date: 05/17/2018 Job ID: JN -052018-21623 Job Type: Scientific
The Protein Homeostasis TCoE is built on our legacy IMiD compounds, which exhibited therapeutic efficacy in erythema nodosum leprosum, myelodysplastic syndrome, multiple myeloma, as well as systemic lupus erythematosus. This class of drugs triggers the degradation of disease-causing proteins that are otherwise considered untruggable . The early drug discovery team in the PH TCoE is now seeking a full-time associate scientist to assist the development of novel small molecular agents targeting novel protein substrates for degradation to treat a variety of human diseases. The successful candidate will utilize state-of-art biotechnology tools to identify novel substrates and perform target validation for the relevant disease indication. The successful candidate will work collaboratively in a multi-disciplinary environment, and will have the opportunity to work closely with discovery project teams and scientists across the PH TCoE functional areas and to present his or her work at project team meetings and to the senior research leadership.

Responsibilities will include, but are not limited to, the following:

Perform high-throughput protein-protein interaction and protein degradation screens
Generate stable cancer cell lines via retroviral or lentiviral transduction
Conduct various cell based assays to characterize drug candidates
Data QC and upload into database
Plan and execute scientific experiments related to one or more programs
Design research protocols in collaboration with the principal investigator
Assist senior researchers in executing, conducting analysis and reporting results
Maintain an accurate, comprehensible, current laboratory journal
Train others on new skills and procedures
Communicate results in written and oral presentations
Write protocols, procedures and technical reports

Bachelor s degree in a scientific discipline with at least 5 years research experience or Master s degree with at least 3 years research experience; experience in biotech industry is preferred.
Extensive experience with cellular high-throughput screens and database uploading is highly desired
Extensive wet-lab experience in biochemistry, molecular and cell biology
Highly motivated and strong team player with a high degree of independence
Innovative and critical thinking
Excellent time management and organizational skills
Strong communication skills, both written and oral

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