San Diego Metro Area, CA
The PH TCoE is one of the fundamental research and early development engines delivering therapeutics to patients. As a thematic center, the PH TCoE is agnostic to therapeutic modality or disease area. The group integrates discovery research through translational and early clinical development and focuses on numerous aspects of protein homeostasis including the ubiquitin-proteasome system (UPS), protein translation, and RNA processing and stability. This thematic focus allows the group to capitalize on the cutting edge science that underpins the action of the company s most advanced drugs. Not being bound by disease area or therapeutic modality creates a very dynamic, exciting and creative environment that exploits excellent science in biology, biochemistry, structural biology, computational biology and translational development.
Responsibilities will include, but are not limited to, the following:
Independently design and conduct cell-based, biochemical and immunoassay development with minimal supervision.
Maintain and characterize various cancer cell lines to support drug discovery.
Perform compound profiling studies using in vitro assays, import and organize data in database, and report results to the supervisor and the project team.
Use automation and perform assay miniaturization to increase throughput of cell-based assays, perform moderate to high throughput screening of compound library and validate hits for SAR studies.
Process and analyze large and complex data sets, report results in a well-organized and easy-to- interpret manner.
Support MoA studies to enable the project team to identify lead candidates, help design in vivo efficacy studies and understand potential toxicological liabilities.
Bachelor s degree in a scientific discipline with at least 6 years work experience or Master s degree with at least 4 years of industrial experience in a drug discovery setting.
Previous industrial experience in drug discovery is required.
Strong molecular and cell biology experience
Familiarity with various cellular assays in high-throughput formats and automation equipment.
Strong data handling skills including importing/exporting data into/from database, organizing data for easy interpretation and experience with a variety of scientific/data analysis software applications.
Excellent communication, presentation, collaboration and organizational skills as well as ability to write protocols and technical reports with precision.
Capability to pay attention to details, stay focused on key objectives, and deliver high quality data in a timely and well organized manner is essential.
Ability to work in a fast-paced dynamic team environment, flexibility to adapt to changes with a positive attitude.