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Associate Scientist I or II

San Mateo Metro Area, CA

Posted: 07/29/2019 Job Type: Scientific Job Number: JN -072019-25283
Main Duties and Responsibilities
Individual contributor to join Clinical Pharmacology and Bioanalysis department supporting clinical and pre-clinical PK/PD and non-clinical toxicology studies. Your primary responsibilities will include development, validation/qualification of quantitative mass spectrometry assays to support pharmacokinetic/toxicokinetic/pharmacodynamic analyses in variety biological matrices as well sample analysis. You will utilize mass spectrometry for detection and quantification of therapeutic peptides and antibodies, including ADCs, small molecules and various biomarkers (proteins, lipids, metabolites). You will adhere to established Standard Operating Procedures and contribute to validation protocols, reports and bioanalytical reports. You will demonstrate competency in troubleshooting, optimization and implementation of challenging and innovative LC-MS/MS assays.

Essential Requirements

For Associate Scientist I:
B.S. in Chemistry, Biochemistry or Pharmaceutical Sciences with 5-8 years of relevant experience OR M.S. in Chemistry, Biochemistry or Pharmaceutical Sciences with 2-5 years of relevant experience

For Associate Scientist II:
B.S. in Chemistry, Biochemistry or Pharmaceutical Sciences with 8-10 years of relevant experience OR
M.S. in Chemistry, Biochemistry or Pharmaceutical Sciences wit 5-8 years of relevant experience OR Ph.D. in Chemistry, Biochemistry or Pharmaceutical Sciences with 0-2 years of relevant experience

For both roles:
  • Strong background in analytical biochemistry/chemistry with emphasis on mass spectrometric bioanalysis of biotherapeutics (peptides, antibodies, ADCs), small molecules, biomarkers (proteins, lipids, metabolites)
  • Hands-on experience with chromatographic separation of various analytes by LC and characterization and quantification by MS or MS/MS
  • Significant experience in method development and troubleshooting
  • Proficiency with mass spectrometry software as well as spreadsheet, word processing, and graphical computer programs
  • Experience with automation
  • Good organizational, documentation and technical writing skills
  • Good command of English (written and oral)
  • Strong communication and interpersonal skills

Desirable Requirements
  • Industry experience
  • Small/large-molecule mass spectrometry experience
  • Familiarity with basic pharmacokinetic data analyses
  • Familiarity with metabolite identification and profiling studies
  • Knowledge of chromatographic assay validation guidelines and GLP regulations
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