Associate Scientist - Translational
San Diego Metro Area, CA
This Associate Scientist will be part of the Protein Homeostasis Translational team. The successful candidate will have a broad understanding of molecular cell biology and immunology, with unique expertise in small molecule drug development for therapy of various hematology/oncology diseases.
The incumbent will be responsible for addressing questions of drug scheduling, supporting patient selection hypothesis and developing clinical assays using current techniques and primarily in vitro and ex vivo methods; and is responsible for experiment design, execution and data interpretation for well-defined projects. The position will require handling and compound treatment of human tissues including whole blood, PBMC, bone marrow aspirates, tumor cell lines and primary tumors. The associate will be expected to maintain an electronic lab notebook and organize results into reports or presentations. The ideal candidate will possess strong communication, presentation, writing and record keeping skills.
Relevant technical skills include: qRT-PCR , siRNA/shRNA transfections, tumor cell signaling analysis, MSD/ELISA, Western blotting, isolation of DNA/RNA/protein from cell culture and tissues
Excellent cell culture technique and ability to characterize cancer cell lines and design and perform cell-based assays
Multicolor flow cytometry techniques and analysis
Experience with ex vivo tumor slice cultures or organoids
Microsoft Office Suite proficiency
Excellent organizational and record keeping skills
Good communication and presentation skills
Ability to follow laboratory procedures with attention to detail and successfully execute experiments at the bench
Understand cancer biology, molecular biology and cell biology
MS or BS degree in biology with at least 4 years of demonstrated industrial experience in drug discovery.
A.B.S. degree in a scientific discipline with minimum 6 years of industry experience is also acceptable.
Candidates should be able to conduct experimental protocols with minimal supervision and analyze and troubleshoot experiments.
Knowledge in E3 ubiquitin ligases, transcription factors tumor biology or immunology is a plus.
Strong scientific and reasoning skills, demonstrated scientific flexibility and attention to details.
The qualified candidate will be self-motivated and possess strong interpersonal and communication skills with demonstrated ability for creative thinking and problem solving.