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Associate Scientist / Scientist

San Francisco Metro Area, CA

Posted: 01/18/2019 Job Type: Scientific Job Number: JN -012019-23431
Description:
Seek to deliver truly innovative and life-changing drugs for our patients. Investigational compounds are being studied for patients with hematological and solid tumor cancers, including multiple myeloma, myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), chronic lymphocyte leukemia (CLL), non-Hodgkin's lymphoma (NHL), pancreatic cancer and lung cancer.

Facilitates the transition of drug candidates from drug discovery through early- and late-stage clinical development. Early-stage translational development activities enable rational determination of dose-schedule and responsive patient populations, based on deep understanding of drug mechanism of action. Late-stage translational development activities build upon the early work, additionally exploring mechanisms of resistance, rational drug combinations and product differentiation. The late-stage translational development function is responsible for the development of translational strategies to support the development, and maximize the potential, of therapies post-clinical proof-of-concept, including registrations and life-cycle management.

Technical Skills:
Analysis of cell surface markers and intracellular proteins by multi-color flow cytometry
Ability to analyze flow cytometry data by FlowJo or a similar software
Experience with cell suspension preparation from mouse tissues is a plus
Expertise in cell culture of mammalian cell lines and primary cells
Cell-based assays for growth/viability and signal transduction
Immunohistochemistry and immunofluorescence technique is a plus
Core cell biology skills including microscopy, Westerns, immunoprecipitation, ELISA etc
Knowledge of oncology and immunology is a plus

Scientific Capabilities:
Able to independently design experiments to address a scientific question
Self-directed use of literature to inform project strategies and select experimental methods
Able to critically analyze and interpret data.
First-rate skills in spotting artifacts and troubleshooting assays
Able to select, test and validate protocols and methods
Critically assess project(s) and formulate ideas
Solid understanding of scientific mechanisms and experimental techniques, with knowledge of cancer cell biology preferable

Other Attributes:
Maintain positive and productive working relationships with colleagues
Improve efficiency and productivity within group or project
Understands and aligns with departmental goals and prioritization
Viewed as an experienced resource within the department
Ability to prioritize and manage time efficiently
Excellent oral and written communication skills
Detail-oriented with the ability to identify and implement creative solutions
Strong motivation to carry out rigorous, well-controlled experiments
Strong motivation to improve cancer treatment

Responsibilities:
Execute experiments independently
Analyze, interpret and discuss data and troubleshoot
Train other research associates and scientists in lab assays of expertise
Understand the context, impact and timely communication of data
Search literature for targeted information
Work with human and mouse bone marrow, spleen, blood and other tissue samples
Actively participate in the development of cell-based assays for mechanistic studies, including biomarker work
Perform a wide range of assigned research experiments with efficiency, accuracy and attention to detail
Meticulous record keeping
Willingly share information and resources
Interact with manager and project team to review data and plan next steps
Prepare and present work at group meetings
Flexible to changing priorities
Respectful of laboratory safety policies and practices

Requirements & Education:
The candidate must have a Bachelors degree in the Life Sciences with 4 or more years industry experience or a Masters degree, with a minimum of 2 years of additional experience in a research environment. Must be willing to work with a highly motivated team, pursuing goals aggressively. The candidate will be technically superb, independent, detail oriented, well organized, and enjoy working in a fast-paced environment.
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