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(Sr.) Scientist - Statistical Genetics

Marin Metro Area, CA

Posted: 11/13/2018 Job Type: Scientific Job Number: JN -112018-23050
RESPONSIBILITIES
  • Apply and develop robust statistical and computational approaches to analyze SNP array, whole-exome and whole-genome sequence data in combination with phenotypic data to enable disease/target/biomarker identification and evaluation, exploring mechanism of action, and identification of genetic causal links to disease or subtypes of disease
  • Work closely with project teams and functional areas to identify and provide computational solutions to address key biological questions, including identifying datasets, formulating hypothesis, developing and implementing analytical solutions
  • Evaluate bioinformatics methods to integrate, summarize and report genetic, genomic, and other omics data, examples include GWAS, RVAS, Mendelian randomization, RNA-seq, scRNA-seq, WES/WGS.
EXPERIENCE
  • Solid foundation in population statistical genetics principles and applications
  • Demonstrated knowledge and expertise with NGS and statistical genomics analyses and software
  • Hands-on experience in management, analysis and interpretation of large human genomics studies (e.g. GWAS, Mendelian randomization, ENCODE)
  • Statistical programming and scripting skills (R and Python/Perl/Shell/etc.)
  • Demonstrated ability to work in cross-functional teams and being a highly collaborative and active team contributor
  • Strong scientific curiosity and initiative, knowledge of experimental design
  • Excellent problem-solving, teamwork, organization and communication skills
  • Working experience with large samples combining broad phenotypic information or Electronic Health Record data with genotype/sequence data will be a plus (eg. UK Biobank, National Registries, TopMed).
  • Working experience of integrating GWAS analysis with molecular profiling data will be a plus (e.g. eQTL, pQTL
EDUCATION
  • Ph.D., minimum of 1-2 years post degree experience (preferred 5-7 years) in statistical genetics, quantitative genetics, biostatistics, computational biology, or related fields
SUMMARY
We re seeking a statistical geneticist/genomicist to join the growing research and drug discovery group. The Sr Scientist / Scientist will support the discovery activities to transform human genetics and genomics discoveries to therapeutic hypotheses, and effectively communicate results to impact multiple stages of our drug discovery and development pipeline. The successful candidate will have the opportunity to work in a fast-paced and highly collaborative environment and will be responsible for developing and employing rigorous statistical and computational approaches and to engage fellow scientists and project teams to leverage genomics data in achieving project objectives.
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