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Snr Associate Scientist - Cellular Immunology

San Diego Metro Area, California

Post Date: 09/06/2017 Job ID: JN -092017-19957
  • BS or MS in Molecular Biology or related with 6 - 8 years industry Experience
  • The qualified candidate will participate in testing novel antibody candidates in functional assays in addition to performing mechanism-based in vitro studies.
  • Will implement existing HTS platforms to assess target binders for functionally in relevant systems to support multiple programs at varying stages of antibody discovery.
  • Design and execute complex human cell based assays and mechanism of action studies. Also, perform routine and complex data analysis to triage leads for affinity maturation.
  • Isolate and expand human primary immune cell populations for in vitro functional assays.
  • . Perform routine Biotherapeutics assays on identified antibody leads prior to DC nomination, including Fc R binding, effector function, and human cytokine release.
  • Cross-trained in multiple flow cytometry platforms. Also have the capacity to assist colleagues in performing flow analysis.
Routine presentations of experimental plans and data in team and department settings

Skills/Knowledge Required:
  • Familiar with multi-parameter flow cytometry analysis (surface/intracellular staining) using LifeTechnology Attune, BD Celesta FACsCalibur etc. Experience in High Content Imaging system a plus.
  • Proficiency with FlowJo, Prism, Microsoft office applications
  • Expert understanding in tissue culture, human and cynomolgus immune cell isolations, and familiarity with gene reporter systems.
  • Solid understanding of cellular immunology.
  • Familiarity in molecular and biochemistry techniques, including cell transfections, Western blotting, DNA manipulations, and qPCR analysis, are desired.
  • Fundamental knowledge and understanding of drug discovery and antibody discovery process is preferred.

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