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Scientist

San Diego Metro Area, CA

Post Date: 03/13/2017 Job ID: JN -032017-18594
Job Responsibilities:
Develop, characterize and optimize assay biochemistry, workflow automation and HW.
Recognize potential problems, understand and troubleshoot genomic assays and associated equipment and HW
Independently plan, conduct, analyze, interpret, and report recommendations based on tested experimental results.
Conduct experiments and analyze data to support a robust supply of key components of the Infinium Assay
Independently plan and execute verification and validation testing of new Array assay workflows and automation software. Complete verification and validation reports in accordance with the appropriate good documentation practices
Analyze large complex data sets with statistical methodology
Develop hypothesis and statistically relevant data sets to prove correlations between physical and biochemical metrics
Participate in fast paced multidisciplinary development and troubleshooting teams.
Conduct focused independent research and development activities.
Drive technical aspects of new genomic assay development forward through a deep knowledge of biochemistry / molecular biology and liquid handling automation / fluid dynamics and data driven risk assessments
Keep a laboratory notebook, write reports and prepare presentations for peers to team management on own work and its implications to the program
Become an expert in Illumina s BeadArray assays including, but not limited to, Infinium Genotyping, Methylation, and Copy number variation.
Deliver results in a fast-paced, results orientated, product development environment
Perform other duties as assigned.

Skills and Experience:
PhD in Molecular Biology, Genomics, Biochemistry, Bioengineering, or related field with an applied or application specific focus and a minimum 1 year of industrial experience
Hands-on experience with development and optimization of workflows, hardware and liquid handling automation for biochemical assays.
Proven experience in the design, planning and execution of system / workflow level verification and validation studies
Record of process driven approach to experimental design and troubleshooting, including understanding of DOE and statistical analysis / scripting software such as JMP and R
Proven ability to work independently to solve cross functional scientific problems
Deep hands on and theoretical knowledge of molecular biology methods for nucleic acid analysis and manipulation including purification, amplification, labeling, hybridization for both DNA and RNA.
Proven record of troubleshooting assay processes to deliver root cause and robust fixes
Practical experienced with physical characterization metrology (topology, surface energy, fluid dynamics etc.)
Excellent verbal/written communication and interpersonal skills.
Flexible and adaptable.
Analytical, detail-oriented, organized, takes initiative, and self-motivated.
Technical understanding of SNP genotyping analysis tools a benefit
Excellent lab notebook and documentation skills.
DNA Array experience preferred.

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