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Research Associate

San Diego Metro Area, CA

Post Date: 04/05/2017 Job ID: JN -042017-18759 Industry: Bioanalytical - Scientific
Description:

CORE JOB FUNCTIONS:
  • Primarily be responsible for developing and performing binding assays, kinetic profiling assays, competition assays, efficacy assays and epitope binning of early therapeutic candidates using a wide range of biophysical and biochemical methods including Biacore, MASS-1, Octet, FRET, ELISA, etc.
  • Implement and validate protocols.
  • Reviewing literature for technical support.
  • Data analysis.
  • With assistance, executes experiments, conducts analysis and reports results.
  • Work with minimal direction to complete assigned tasks.
  • Consults colleagues for advice on issues.
  • Recognize unexpected outcome/problems; communicates and works with supervisor to solve.
  • Learn from the past experience to improve the current process.
  • Communicates with peers and supervisors.
  • Begin to communicate with departments and customers.
  • Works in context of immediate work group or team.
  • Has a direct impact on workgroup performance.
  • Impact is achieved by contributing to workgroup.

KNOWLEDGE/SKILLS/ABILITIES (KSA's):
  • At least 2 years of industry experience in bioanalytical and biophysical characterization of monoclonal antibodies, Fc-fusion proteins, peptides and antibody-drug conjugates (ADCs).
  • ***MUST have experience with Bicaore or SPR instruments.***
  • Proven track record of developing binding assays for monoclonal antibodies and other forms of biologics candidates using all or any of the following techniques: Biacore, MASS-1, Octet, HTRF, AlphaScreen, ELISA.
  • Thermal stability determination using DSC, DSF and formulation screen to identify ideal storage buffer condition.
  • Experience in SDS PAGE is a plus.
  • Antibody conjugation experience is a plus.
  • Experience in protein expression and purification is a plus.
  • Mass spectrometry: Intact mass determination of antibodies and Fc-fusion protein can be an added advantage.
  • Excellent written and oral communication skills including ability to present scientific data in group setting.
  • Excellent organization to multi-task and manage multiple projects.
  • Ability to adapt to rapid changes in projects priorities and meet aggressive timelines
  • Committed to working in a collaborative manner across functional areas within matrix organization
  • Have mastery of basic lab skills.
  • Familiarity with data retrieval and input from database.
  • Familiarity with work and business practices to be able to identify and troubleshoot routine problems.
EDUCATION:
  • Bachelor s or Master s degree in Biochemistry or related discipline with 2 years of hands on experience in industry focusing on Biologics

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