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Downstream Process Development

San Mateo Metro Area, CA

Post Date: 08/11/2017 Job ID: JN -082017-19768
The Process Development team is looking to bring on board a Downstream Process Development Engineer to help support the continued development, manufacturing and commercialization of our vectors for our therapies that address both our rare diseases programs as well as our Ophthalmology programs.


  • MS with 2-4 years of experience or BS with 4+ years of experience in Chemical Engineering, Biochemistry, Cell & Molecular Biology or related life science engineering fields.
  • Highly motivated team player capable of leading by example and who exceeds expectations in all aspects of the role.
  • Experience with protein purification including hands on experience with TFF, UD/DF, GE AKTA, chromatography at small/pilot/large scale is required.
  • Hands-on experience in the insect cell-baculovirus expression technology platform is a plus.
  • Broad experience in cGMP, biologics, and manufacturing and understanding of regulatory guidelines is preferred.
  • Experience drafting SOPs, Batch records, reports, and protocols is required.
  • Pursue work with the goal of (1) improving the existing purification process and (2) develop novel manufacturing processes with the highest quality on time to advance the product pipeline.
  • Design and execute experiments following appropriate laboratory procedures and produce competent and reproducible results to a high technical standard.
  • Appropriately analyze data, interpret results, and maintain accurate records with minimum supervision.
  • Interact with Assay Development, QC, QA, and pre-clinical group.
  • Ensure safe work place in compliance with the company and EHS' rules and regulations.
  • Work hands-on to develop, optimize, and scale-up downstream processes using small to large scale purification systems in the laboratory setting for the purification of AAV vectors.
  • Keep current with advances in downstream processes for viral vector production.

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